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Hi! Welcome to Sharon's Lupus Page!
Reach high, for stars lie hidden in your soul. Dream
deep, for every dream precedes the goal. - - - - Ralph Vaull
Starr
The Anatomy Of Lupus
Hi there, I will try to be of some help if I can. The answer to the
question I get most, which is about imflamation and swelling, is found in
the very cells of your body, specifically the cells of your immune
system. I will start with a look at the healthy immune system and how it
goes awry with lupus.
The immune system is the body's defense team so to
speak. It's a network of cells that guard the body against an outside
world of potential enemies, such as bacteria, parasites, viruses,
fungi.
The wonder to me of the immune system is its ability
to distinguish the "self" from the "nonself"--substances that rightly
belong to the body from those that don't. Almost every cell in the body is
marked by a molecule that signals "self". This includes cells from every
body system --the heart, lung, blood, tissues, et cetera. The healthy
immune system knows to leave these marked cells alone. But anything that
isn't a "self" molecule-carrying member of the body catches the attention of
the defense team and triggers and immune response. The "nonself" proteins
that trigger an immune response are known as antigens. That word literally
means "against a species".
Stationed throughout the body are organs that
breed and nurture the varied members of the immune system's defense team.
They are known as lymphoid organs, They include-- The tonsils and
adenoids The lymph nodes The thymus The spleen Peyer's
patches The appendix The bone marrow The lymphatic vessels
Like
all cells, the immune system's defense team is born in the bone
marrow. Some of these cells grow up to become lymphocytes, while others
become phagocytes. Immune cells then travel to the immune organs, where
they wait for signals to launch an attack against any
intruder.
Lymphocytes-- Also called lymph cells, lymphocytes are
small white blood cells that carry out much of the immune defense. There
are three types: B cells, T cells and natural killer cells. (I can go
into more detail about each one if you wish).
Phagocytes-These are large
white cells which, true to their name, eat ("phago") cells ("cytes") and
digest them. Or they trap the antigen and hand it over to B cells or T
cells. This group of cell-eaters includes monocytes, macropghages, and
Granulocytes. (I can also go into more detail here if you
wish).
COMPLEMENT----------- The COMPLEMENT system is a group
of more than twenty proteins which in their effort to control infection
contribute to inflammation. The linking of antibody to antigen
stimulates a chain reaction of complement. At the end of this chain is a
membrane attack complex--a kind of sword that punctures the target antigen,
causing it to explode. In people with lupus, levels of complement are
lower than normal, either because of the high level of inflammation or
because of a disease-related problem in producing it.
Inflammation--In
inflammation, complement signals blood vessels to open up wider, ushering
in more blood--and defenses-to fight off the antigen. This is what causes
the redness of inflammation around an infected area. The
macrophages, called to the batttle site by T cells, release toxic
substances that help them digest immune complexes. (While these substances
often help in defense, they can also spill out into healthy tissue and
start mistakenly eating away at it, as though it were antigen.)
Complement also makes the vessels leaky, allowing white cells to pour into
tissue. This is what causes the swelling and tenderness of
inflammation.
Once the offending antigen is under control, T cells
call a halt to the immune reaction. Ending the immune response is just as
important as starting it. If the T cells don't signal an end to immune
activity, the inflammatory process will continue uncontrolled. With Lupus
this overzealous immune reaction can cause direct harm to your body. I can
go into how this team works together if you wish, just email me.
The
Lupus system, like the allergic immune system, suffers from a serious case of
myopia. It mistakes the self for nonself. As a result, the immune system
attacks the very being it's meant to protect: the self. To put it another
way, the body acts as though it were suddenly allergic to its own blood.
The body's own cells, tissues and organs become the innocent targets
of antibodies (or autoantibodies, because they are directed against the
self.) Instead of attacking alien substances, the misguided autoantibodies
target healthy cells, cell components and tissue. They react against the
fundamental structure of cells--the nuclei(core) of cells and part of the
cell walls(phospholipids).
In people with Lupus, the immune system
falters on several other levels: the B cells are hypercharged and the team
of suppressor T cells is understaffed. As a result, not only does the immune
system attack the wrong target (cells from its own body), but the immune
response gets out of control.
Another major problem is that the
antibody-antigen complex, normally swept out of the bloodstream my
macrophages, cannot be removed. It lingers and accumulates on tissues.
Remember--the complexes activate complement, which ends in
inflammation. In Lupus, these immune complexes cause inflammation wherever
they settle.
I can address the meds and treatment for Lupus if anyone
wants or needs that information, please email me. I can also address the
Depression and coping with Lupus if you wish.
Please sign
my guest book and let me know what you think of this novice's work so
far!
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